While there is much in flux about Gus Van Sant’s upcoming adaptation of Tom Wolfe’s Zeitgeist-defining book, “The Electric Kool-Aid Acid Test,” which centers on the LSD-infused cross-country road trip that novelist Ken Kesey and his Merry Pranksters took in the 1960s, the director is certain about one thing: he won’t be able to cast his ideal leading man.

“Unfortunately, Heath Ledger was a pretty obvious choice, and he’s gone,” Van Sant told MTV News in an exclusive interview. But who else could play zany philosopher-king and “One Flew Over The Cuckoo's Nest” author Kesey?

“There’s the opportunity that it could be Jack Black,” says Van Sant, hinting the film might possibly take on a more comedic feel. Read more...